Characterization of the regulatory landscape of IL-17-producing human MAIT cells — ASN Events
  1. Schedule
  2. Lunch & Poster Session 2
  3. Characterization of the regulatory landscape of IL-17-producing human MAIT cells

Characterization of the regulatory landscape of IL-17-producing human MAIT cells (#160)

Katie Healy 1 2 3 , Tim Kosfeld 4 5 , John Scanlan 6 , Grace Guan 1 , Martin Brennan 6 7 , Brenneth Stevens 6 7 , Matthew Fischer 1 , Yuri Pritykin 4 5 , Lydia Lynch 1 2 7
  1. Ludwig Cancer Research Institute, Princeton University, Princeton, NJ, USA
  2. Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
  3. Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
  4. Computer Science, Princeton University, Princeton, NJ, USA
  5. Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
  6. School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
  7. Molecular Biology, Princeton University, Princeton, NJ, USA
Publish consent withheld
  1. Garner LC, Amini A, FitzPatrick MEB, Lett MJ, Hess GF, Filipowicz Sinnreich M, Provine NM, Klenerman P. Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity. Nat Immunol. 2023 Sep;24(9):1565-1578. doi: 10.1038/s41590-023-01575-1. Epub 2023 Aug 14. PMID: 37580605; PMCID: PMC10457204.
  2. Cole S, Murray J, Simpson C, Okoye R, Tyson K, Griffiths M, Baeten D, Shaw S, Maroof A. Interleukin (IL)-12 and IL-18 Synergize to Promote MAIT Cell IL-17A and IL-17F Production Independently of IL-23 Signaling. Front Immunol. 2020 Nov 20;11:585134. doi: 10.3389/fimmu.2020.585134. PMID: 33329560; PMCID: PMC7714946.
  3. Wang H, Souter MNT, de Lima Moreira M, Li S, Zhou Y, Nelson AG, Yu J, Meehan LJ, Meehan BS, Eckle SBG, Lee HJ, Schröder J, Haque A, Mak JYW, Fairlie DP, McCluskey J, Wang Z, Chen Z, Corbett AJ. MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection. Sci Immunol. 2024 Dec 6;9(102):eadp9841. doi: 10.1126/sciimmunol.adp9841. Epub 2024 Dec 6. PMID: 39642244.